Research
Our Center conducts a large number of research projects. The scope of research projects ranges from studies of potential neuroprotective agents for Parkinson's disease (medications that can slow progression of the disease), to novel treatment options to improve the control of PD symptoms, to investigating the role of physical therapy and other non-pharmacological interventions in the management of PD. We actively collaborate with basic scientists in the University to bring their discoveries to patient care. Every patient seen at our Center is encouraged to participate in the research projects. Additional information regarding specific studies can be obtained on this website or by calling 312-503-2593.
Clinical Trials
Consider making a personal contribution to research by participating in a clinical trial. Clinical research may lead to the discovery of new possibilities in the control or the delay of Parkinsonian symptoms. If you are interested, you may fill out a form on our site, call the center at 312-503-2593, or fax us at 312-908-5073.
All study-related care is provided at no charge, including:
- Physician visits and physical examinations
- Laboratory services
- Study medication
Neuroprotection Exploratory Trials in Parkinson's Disease (NET-PD):
The objective of this study is to determine if creatine is more effective than placebo in slowing the clinical decline in PD patients with early, treated PD.
Rotigotine Patch for Advanced PD:
The purpose of this study is to evaluate the safety and effectiveness rotigotine in patients with advanced-stage Parkinson’s disease.
Light PD Therapy:
This study is using light boxes as possible treatment for people with PD who are excessively sleepy during the day. Study involves 2 weeks of at home light treatment, 2 overnight sleep studies, and 3 clinic visits.
REM Behavior Disorder:
This study is looking at the effects of the FDA approved drug Rozerem on patients with Parkinsonian disorders who act out their dreams. The study requires the subject to take study medication (Rozerem vs. placebo) for 8 weeks and subjects must have a bed partner who is willing to participate in filling out daily sleep logs.
Impulse Control Disorders:
This study involves imaging the brains of PD patients with impulse control disorders to better understand the underlying mechanisms and brain regions associated with impulse control disorders. The study requires one clinic visit and one fMRI-imaging scan.
Posture Assisted Locomotion Training (PAL):
The objective of this study is evaluate a new technique to improve stepping and walking in persons with Parkinson’s Disease (PD). The study includes 12 training sessions that occur two times per week for six weeks and pre/post testing. A medical screening is required for enrollment.
Preparation for Gait Initiation:
This is a physical therapy study that involves one 3-hour session of testing with the participant OFF their medications.
Parkinson Associated Risk Study (PARS):
The objective of this study is to test the sense of smell and imaging of the dopamine system of the brain in individuals with a relative diagnosed with Parkinson’s disease at the Parkinson’s Disease and Movement Disorder Center of Northwestern University.
PROGENI:
This study is looking for brothers and sisters with Parkinson’s disease. The study involves an interview with family members, one clinical exam and collection of blood samples. The study is funded by The National Institutes of Health.
Deep Brain Stimulation and Speech (DBS):
This study is for people who are scheduled to undergo electrode implantation for subthalamic nucleus deep brain stimulation (STN DBS) or who have already undergone the procedure, and the impact of this procedure on speech and swallowing. Participation will involve 2-4 visits that will last approximately 2-3 hours in length.
Genetics:
The objective of this study is to identify the genetic basis of neurodegenerative disorders, characterized by disorders of movement or gait. Subjects with a movement disorder will be asked to give a blood sample which will be used to investigate the effects of the mutations at the cellular level and explore mechanisms of neurodegeneration, with the goal of developing methods of stopping disease progression and improving therapeutic strategies.